Reformulated antibodies could be injected for easier treatment
MIT researchers led by Professor Patrick Doyle developed microfluidic-produced hydrogel microparticles that encapsulate highly concentrated antibodies, enabling injection through a standard 2 mL syringe with below-20 N plunger force. The 100 μm semi-solid particles allowed administration of more than 700 mg per syringe, remained stable under refrigeration for at least four months, and will next be tested in animals while the team addresses manufacturing scale-up.
Why it mattersMIT's microfluidic hydrogel-particle antibody formulation enables 700 mg dosing via 2 mL syringes, simplifying outpatient delivery decisions.
Entities Mentioned
MIT
People Mentioned
Patrick Doyle