Partial Reprogramming of Neurons Encoding Memory Improves Cognitive Function in Aged Mice
Partial reprogramming with OSK Yamanaka factors in memory-encoding engram neurons restored youthful epigenetic and transcriptional states, reduced hyperexcitability, and reversed senescence-related hallmarks in aged and Alzheimer's disease mouse models, producing memory performance comparable to young animals when applied to hippocampal and medial prefrontal engram populations.
Why it mattersPrioritize OSK gene-therapy safety and delivery studies targeting hippocampal engram neurons before clinical translation.