One-carbon-derived bioactive peptides improve reproductive performance via regulating placental nutrient transport and offspring glycolipid metabolism
Pichia pastoris-derived short-chain peptides (PpBP) given to sows from late gestation through lactation reduced intrauterine growth restriction and improved piglet growth. The peptides upregulated intestinal PEPT1, altered placental glucose and lipid transporter expression, modulated p38 MAPK and p-AKT signaling, and shifted neonatal hepatic metabolism toward gluconeogenesis.
Why it mattersMaternal 2 g/kg PpBP reduced IUGR via PEPT1 activation and placental transporter changes.