NewBiologix: Announces Publication of Breakthrough HEK293 Cell Line Optimized for High-Quality rAAV Production
NewBiologix published peer-reviewed characterization of NBX1P01, a clonal HEK293 cell line optimized for rAAV production that showed a two-fold higher full-to-empty capsid ratio versus a commercial HEK293 line, genomic stability across 55 population doublings, >70% intact rAAV genomes by long-read sequencing, minimal encapsidated contaminating DNA, and consistent scalability from 10 mL to 1.5 L supporting multiple serotypes and clinically relevant transgene sizes.
Why it mattersNBX1P01's two-fold higher full-to-empty capsid ratio enables manufacturers to reduce purification costs and timelines.