New drug target discovered for devastating “brain on fire” disease
Cryo‑EM maps antibody binding sites on NMDA receptors in an active immunization model of anti‑NMDAR encephalitis. The study identifies antigenic hotspots that point to new druggable targets.
Why it mattersCryo‑EM mapping of NMDA receptor antigenic hotspots identifies druggable epitopes in anti‑NMDAR encephalitis.