Nearly 200,000 people reveal the real key to heart health
A decades-long analysis of nearly 200,000 U.S. adults found that both low-carbohydrate and low-fat diets were tied to lower coronary heart disease risk only when they emphasized whole grains, plant-based foods, and healthy fats; diets high in refined carbohydrates or animal fats increased risk, and metabolomic biomarkers aligned with healthier patterns, though self-reported intake and a health-professional participant pool limit generalizability.
Why it mattersMetabolomic biomarkers linked to coronary heart disease suggest clinical trials should test whole-grain, plant-rich diets for cardiovascular endpoints.