More Confirming Data for Adult Human Neurogenesis
Multiomic single-cell analysis of 355,997 nuclei from human hippocampi across young adults, aged adults, SuperAgers, preclinical-pathology cases, and Alzheimer's disease (AD) samples identifies neural stem cells, neuroblasts, and immature granule neurons and links dysregulated neurogenesis to altered chromatin accessibility. Early chromatin-accessibility changes are detectable in preclinical AD and amplified in AD, SuperAgers exhibit a distinct neurogenic ‘‘resilience’’ signature, and astrocyte plus CA1 neuron profile alterations associate with cognitive deterioration.
Why it mattersChromatin-accessibility changes in preclinical AD point to hippocampal neurogenesis biomarkers for early drug targeting.