Mayo Clinic discovers rare gene mutation that causes fatty liver disease
Mayo Clinic researchers identified a rare MET gene mutation that directly causes metabolic dysfunction-associated steatotic liver disease by impairing hepatic fat processing and promoting inflammation and scarring. The discovery began with a father–daughter pair lacking typical risk factors, and population genomic analyses indicate similar rare MET variants may be under-recognized contributors to the disease.
Why it mattersAfter identification in a father-daughter pair, MET variant screening enables earlier diagnosis of MASLD.
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Mayo Clinic