Male obesity causes adipose mitochondrial dysfunction in F1 mouse progeny via a let-7-DICER axis
Mouse study finds paternal obesity raises sperm let-7 microRNAs that silence DICER1 in offspring adipose tissue. This suppresses mitochondrial gene expression and causes glucose intolerance; human semen let-7d/e falls after male weight loss.
Why it mattersPaternal high-fat diet elevated sperm let-7d/e, silencing offspring adipose DICER1 and causing glucose intolerance.