Internal gelation-based alginate hydrogel films incorporating Quercus infectoria gall extract for multifunctional wound dressing applications
Researchers developed alginate hydrogel films loaded with Quercus infectoria gall extract using internal gelation. The optimized films exhibited high wound-fluid uptake (716.18 b1 25.05%), balanced water vapor transmission (~1,304 g/m2/day), ~80% optical transparency, and encapsulation efficiency >99%; they released ~62.6% of extract in 24 hours. In vitro tests showed strong antioxidant activity, a 50.08 b1 3.19% reduction in nitric oxide production in LPS-stimulated macrophages, and up to 99.99% bacterial growth inhibition after 24 hours, supporting their potential as multifunctional natural wound dressings.
Why it mattersAlginate–QIG films achieved 99.99% bacterial inhibition and >99% encapsulation efficiency; pursue preclinical safety and GMP scale-up.