How a Sirtuin Protects Against Brain Diseases
Aging Cell researchers report that SIRT6 maintains nucleolar structure to limit rRNA synthesis and prevent protein overproduction and aggregation linked to neurodegeneration; results across cultured cells, mice, and C. elegans implicate 4PBA and caloric restriction as potential interventions.
Why it mattersSIRT6 loss drives nucleolar expansion and proteotoxicity, so prioritize SIRT6-targeting screens for neurodegeneration.