FMO-2 Upregulation is Common to Multiple Longevity Associated Mutations in Nematodes
In C. elegans, FMO-2 is specifically upregulated and required for lifespan extension in mitochondrial longevity mutants clk-1, isp-1, and nuo-6. The study shows FMO-2 acts as a common downstream effector of multiple longevity pathways, with HLH-30, NHR-49, MDT-15, DAF-16, PMK-1, SKN-1, CEH-23, AAK-2, HIF-1 and ELT-2 implicated in its regulation.
Why it mattersFMO-2 mediates lifespan extension in clk-1, isp-1 and nuo-6 C.