Enhancing wound healing with synergistic dual-drug electrospun roflumilast and L-arginine loaded PLA/PVA nanofibers through fabrication, optimization, and in vivo assessment
Electrospun PLA/PVA nanofibers co-loaded with roflumilast and L-arginine showed ~99.8% wound closure in a rat excision model by day 14, with controlled swelling, confirmed drug incorporation, and improved histological re-epithelialization versus single-drug and control groups, indicating a promising topical regenerative dressing platform.
Why it mattersRoflumilast and L-arginine PLA/PVA nanofibers achieved 99.8% rat wound closure, prompting GLP preclinical scale-up.