Enhancing Mitochondrial Function Improves Memory in Flies and Mice
Knockdown of the mitochondrial Ca2+ exporter Letm1 increased mitochondrial Ca2+ retention, over-activated neuronal metabolism, and improved long-term memory in both flies and mice, revealing an evolutionarily conserved link between mitochondrial energy capacity and memory formation.
Why it mattersLetm1 knockdown boosted LTM in flies and mice; consider mitochondrial Ca2+ handling as a therapeutic target for cognitive aging.