The RAPA-EX-01 randomized double-blind trial assigned weekly 6 mg sirolimus with exercise in 65–85-year-olds and found modestly smaller improvements in 30-second chair-stand performance versus placebo.
Key Takeaways
- RAPA-EX-01 randomized 40 sedentary adults aged 65–85 to 6 mg weekly sirolimus or placebo for 13
- Primary outcome was change in 30-second chair-stand repetitions
- ITT result did not reach conventional significance (p=0.089)