An Aging Clock to Predict Time Until First Alzheimer's Disease Symptoms
Researchers developed an aging clock using plasma p‑tau217 to predict time until first Alzheimer's symptoms. The model, tested across two cohorts (total n≈603), estimated symptom onset with a median error of 3–4 years and found shorter p‑tau217-to-symptom intervals in older participants.
Why it mattersPlasma p‑tau217 predicts symptom onset within 3–4 years, informing timing for preventive trials and participant selection.