A View of Age-Related Changes in the Features of Extracellular Vesicles
Researchers analyzed plasma extracellular vesicles across age groups using size-exclusion chromatography, surface profiling, nanoparticle tracking, and small RNA sequencing. They observed age-linked decreases in adaptive-immune EV markers (CD3, CD56, HLA-A, CD45) and increases in monocyte/activation markers (CD14, CD69). EV miRNA signatures (including miR-206, miR-143-3p, miR-122-5p, miR-20b-3p, miR-6529-5p) and particle counts correlated with GDF-15, visceral fat, and muscle quality, supporting EVs as candidate minimally invasive biomarkers of biological aging.
Why it mattersEV miRNA profiles (small RNA sequencing) track GDF-15 and muscle quality, informing biomarker selection for aging trials.