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A tunable autonomous RNA-fueled micro-engine

Source: Nature - Biotechnology | Published: 2026-02-25T00:00:00+00:00

A tunable autonomous RNA-fueled micro-engine

Researchers built a tunable, RNA-fueled DNA-origami engine that drives cyclic motion of a 500 nm particle. The system uses RNADNA hybridization and RNase H cleavage to switch reversibly and can be sequence-addressed for programmable, self-resetting nanomechanical action.

Why it mattersSequential RNA–DNA switching drove cyclic motion of a 500 nm particle, enabling programmable, self-resetting nanocarrier transport.

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