A new way to rejuvenate the immune system
MIT and Broad Institute researchers encoded three thymic maturation factors into lipid‑nanoparticle mRNA that reprograms hepatocytes, restoring T‑cell numbers and diversity and improving vaccine and cancer‑immunotherapy responses in aged mice.
Why it mattersMIT's LNP-delivered mRNA reversing thymic decline implies funders should prioritise preclinical safety and translation pipelines.
Entities Mentioned
MITBroad Institute