A Metabolic Shift Fuels Stem Cell Dysfunction
Researchers found age-related downregulation of IGF2BP3 impairs glutathione (GSH) metabolism in human adipose-derived stem cells (hASCs). Older hASCs showed increased senescence, poorer regenerative performance in mouse transplantation, and partial functional rescue with BCAA and glutamine supplementation.
Why it mattersIGF2BP3 hypermethylation and reduced GSH in aged hASCs indicate metabolic modulation could improve autologous stem cell therapies.
Entities Mentioned
Cell Discovery