A CAR T Cell Therapy to Target Amyloid Plaques in the Brain
Preclinical study reports CD4+ CAR‑T cells targeting fibrillar amyloid‑β reduced parenchymal amyloid and altered dura deposition while recruiting endogenous CD4+ cells in mouse Alzheimer's models, supporting CAR‑T as a potential neurodegenerative immunotherapy.
Why it mattersCAR‑T targeting amyloid‑β suggests funders should prioritize preclinical neuroimmunology programs to accelerate AD translational development.